The accuracy of a homology model based on the structure of a distant relative or other topologically equivalent protein is primarily limited by the quality of the alignment. K*Sync uses a systematic approach for sequence-to-structure alignment in which alignments are generated by dynamic programming using a scoring function that combines information on many protein features, including a novel measure of the obligateness of a sequence region to the protein fold. This approach has been demonstrated to be effective at both generating and selecting accurate alignments. The method serves as the foundation of the homology modeling module in the Robetta server. K*Sync software was developed by Dylan Chivian and David Baker.
K*Sync is one of the many software programs and tools created at the University of Washington available through our Express Licensing Program. These agreements have standard terms and conditions that allow for rapid licensing by companies, organizations, or individuals.
An academic license is available to users at academic and nonprofit research institutions at no charge. Please click on the "License" button to access the academic license.License
For commercial license to K*Sync, please contact the Express Licensing Program.